Gt(ROSA)26Sor^{em1(CAG-Jmjd4)Dxu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Jmjd4)Dxu}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Dachun Xu
• MGI ID: MGI:7714894
• Synonyms: Jmjd4^OE-flox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Jmjd4)Dxu} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(CAG-Jmjd4)Dxu} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Jmjd4 (MGI:2144404)

• Gt(ROSA)26Sor^{em1(CAG-Jmjd4)Dxu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: A mouse Jmjd4 expressing cassette driven by the CAG promoter with a loxP-STOP-loxP element between the CAG promoter and Jmjd4 was inserted into the locus via CRISPR/Cas9 technology. Jmjd4 is expressed only upon removal of the STOP element via cre-mediated recombination. (J:353408)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1084 strains or lines available

References

• Original: J:353408 Tang Y, et al., Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy. Circulation. 2023 May 30;147(22):1684-1704
• All: 1 reference(s)