Rr543^em1Justc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr543^em1Justc
• Name: regulatory region 543; endonuclease-mediated mutation 1, Justin Cotney
• MGI ID: MGI:7713495
• Synonyms: Hoxa^deltaGCR
• Gene: Rr543 Location: Chr6:50650594-51173785 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr543^em1Justc page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The super-enhancer cluster or global control region (GCR), containing dozens of Hoxa craniofacial enhancers, was targeted using sgRNAs with CRISPR/Cas9 technology, resulting in a 523,192 bp deletion (GRCm39:chr6:50650594-51173785). (J:344244)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr543 Mutation: 0 strains or lines available

References

• Original: J:344244 Wilderman A, et al., A distant global control region is essential for normal expression of anterior HOXA genes during mouse and human craniofacial development. Nat Commun. 2024 Jan 2;15(1):136
• All: 1 reference(s)