Fxn^tm1.1Gmnf
Targeted Allele Detail

Summary

• Symbol: Fxn^tm1.1Gmnf
• Name: frataxin; targeted mutation 1.1, Giovanni Manfredi
• MGI ID: MGI:7713084
• Synonyms: KI Fxn⁷⁰⁰
• Gene: Fxn Location: Chr19:24238817-24257969 bp, - strand Genetic Position: Chr19, 19.39 cM, cytoband C1
• Alliance: Fxn^tm1.1Gmnf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:351851
• Parent Cell Line: iTL BF1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Insertion
• Mutation details: The targeting construct inserted the human sequence with GAA repeats expanded to 700 and the neo cassette 1,400 bp downstream of exon 1. Recombination removed the selection cassette. (J:351851)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fxn Mutation: 42 strains or lines available

References

• Original: J:351851 Sayles NM, et al., Comparative multi-omic analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency. Dis Model Mech. 2023 Oct 1;16(10)
• All: 1 reference(s)