Del(5Gbp4-Gbp8)1Mansm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(5Gbp4-Gbp8)1Mansm
• Name: deletion, Chr 5, Si Ming Man; deletion, Chr 5, Si Ming Man 1
• MGI ID: MGI:7712919
• Synonyms: Gbp4^-Gbp8^-Gbp9^-
• Gene: Del(5Gbp4-Gbp8)1Mansm Location: unknown Genetic Position: Chr5, Syntenic

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Del(5Gbp4-Gbp8)1Mansm involves 3 genes/genome features (Gbp8, Gbp9, Gbp4) View all
• Mutation details: CRISPR/Cas9 technology using sgRNA 5-GGTGGAGGCGGGGTATGGTGAGG-3 and 5-CATGGAGAGTGGAATTTGAGAGG-3 targeting upstream of the Gbp4 gene and sgRNAs 5-AGCTCACTGCTTCTCCATACTGG-3 and 5-TTCATCTCTTGTAAGATGGGAGG-3 targeting downstream of the Gbp8 gene generated a 127 kb deletion from the intergenic region upstream of Gbp4 to the intergenic region downstream of Gbp8 and deleted Gbp4, Gbp9, and Gbp8. (J:324833)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(5Gbp4-Gbp8)1Mansm Mutation: 0 strains or lines available

References

• Original: J:324833 Simpson DS, et al., Interferon-gamma primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity. 2022 Mar 8;55(3):423-441.e9
• All: 1 reference(s)