Hipk3^tm1.1Liyx
Targeted Allele Detail

Summary

• Symbol: Hipk3^tm1.1Liyx
• Name: homeodomain interacting protein kinase 3; targeted mutation 1.1, Yangxin Li
• MGI ID: MGI:7709751
• Synonyms: circHIPK3^Flox
• Gene: Hipk3 Location: Chr2:104256826-104324791 bp, - strand Genetic Position: Chr2, 54.74 cM
• Alliance: Hipk3^tm1.1Liyx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:350458
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Modified isoform(s))
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the short interspersed elements (SINEs) downstream of exon 2 and a loxP site and a self-deletion anchor flanked neo cassette were inserted downstream of the SINEs sequence via homologous recombination. Removal of the SINEs sequence impairs circularization of the RNA produced from exon 2. (J:350458)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hipk3 Mutation: 67 strains or lines available

References

• Original: J:350458 Ding F, et al., circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR. Theranostics. 2022;12(17):7550-7566
• All: 1 reference(s)