Del(2Rr509-Rr508)2Jirna
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(2Rr509-Rr508)2Jirna
• Name: deletion, Chr 2, Hiroshi Nakajima 2
• MGI ID: MGI:7709746
• Synonyms: G3SEKO
• Gene: Del(2Rr509-Rr508)2Jirna Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: A Gata3 super enhancer, containing super enhancers 1 (SE1; Rr509) and 2 (SE2, Rr508), was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in a 300.411 kb deletion (GRCm39:chr2:9106869-9407279) in strain 8. (J:350980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Rr509-Rr508)2Jirna Mutation: 0 strains or lines available

References

• Original: J:350980 Furuya H, et al., Stage-specific GATA3 induction promotes ILC2 development after lineage commitment. Nat Commun. 2024 Jul 5;15(1):5610
• All: 1 reference(s)