Rr508^em1Jirna
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr508^em1Jirna
• Name: regulatory region 508; endonuclease-mediated mutation 1, Hiroshi Nakajima
• MGI ID: MGI:7709725
• Synonyms: G3SE2KO
• Gene: Rr508 Location: Chr2:9288652-9407269 bp Genetic Position: Chr2, Syntenic
• Alliance: Rr508^em1Jirna page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Gata3 super enhancer 2 (SE2) was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in a 118.618 kb deletion (GRCm39:chr2:9288652-9407269) and 1 bp (G) insertion. (J:350980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr508 Mutation: 0 strains or lines available

References

• Original: J:350980 Furuya H, et al., Stage-specific GATA3 induction promotes ILC2 development after lineage commitment. Nat Commun. 2024 Jul 5;15(1):5610
• All: 2 reference(s)