Gt(ROSA)26Sor^{tm1(CAG-DICER1*G1809R)Mkur}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-DICER1*G1809R)Mkur}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Masahiko Kuroda
• MGI ID: MGI:7709542
• Synonyms: DICER1^Mut, hDICER1^G1809R
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-DICER1*G1809R)Mkur} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:352925
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-DICER1*G1809R)Mkur} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DICER1 (23405)

  Dicer1

  (MGI:2177178)

  G1809R mutation

• Gt(ROSA)26Sor^{tm1(CAG-DICER1*G1809R)Mkur} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: A CAG promoter, loxP-flanked neomycin resistance gene, and human DICER1 with the p.G1809R mutation was inserted into the locus. The G1809R mutation is a missense mutation in the RNase IIIb domain that is frequently observed in patients with DICER1 syndrome. (J:352925)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1(CAG-DICER1*G1809R)Mkur}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:352925 Oikawa K, et al., Liver-specific DICER1 syndrome model mice develop cystic liver tumors with defective primary cilia. J Pathol. 2024 Sep;264(1):17-29
• All: 1 reference(s)