Del(10Rr502-503)1Issa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(10Rr502-503)1Issa
• Name: deletion, Chr 10, Issam Aldiri 1
• MGI ID: MGI:7709316
• Synonyms: Atoh7-TEN^-
• Gene: Del(10Rr502-503)1Issa Location: unknown Genetic Position: Chr10, Syntenic

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The Atoh7 remote and proximal retinal enhancers were targeted with sgRNAs using CRISPR/Cas9 technology, resulting in an 11.4 kb deletion. (J:351037)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(10Rr502-503)1Issa Mutation: 0 strains or lines available

References

• Original: J:351037 Mehta K, et al., A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis. Cell Rep. 2024 Jun 25;43(6):114291
• All: 1 reference(s)