Rr503^em1Issa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr503^em1Issa
• Name: regulatory region 503; endonuclease-mediated mutation 1, Issam Aldiri
• MGI ID: MGI:7709309
• Synonyms: Atoh7-REN^-
• Gene: Rr503 Location: Chr10:62923109-62927989 bp Genetic Position: Chr10, Syntenic
• Alliance: Rr503^em1Issa page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The Atoh7 remote retinal enhancer was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in a 4.88 kb deletion. (J:351037)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr503 Mutation: 0 strains or lines available

References

• Original: J:351037 Mehta K, et al., A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis. Cell Rep. 2024 Jun 25;43(6):114291
• All: 1 reference(s)