Cacna2d1^tm1.2Gfng
Targeted Allele Detail

Summary

• Symbol: Cacna2d1^tm1.2Gfng
• Name: calcium channel, voltage-dependent, alpha2/delta subunit 1; targeted mutation 1.2, Guoping Feng
• MGI ID: MGI:7707936
• Synonyms: alpha-2delta-1 KO
• Gene: Cacna2d1 Location: Chr5:16139786-16579502 bp, + strand Genetic Position: Chr5, 6.56 cM
• Alliance: Cacna2d1^tm1.2Gfng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266010
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An FRT-flanked neomycin selection cassette and a loxP site was inserted downstream of exon 6 of the targeted gene another loxP site was inserted upstream of exon 6. Flp and Cre-mediated recombination removed the FRT-flanked neo cassette and exon 6. (J:266010)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna2d1 Mutation: 80 strains or lines available

References

• Original: J:266010 Risher WC, et al., Thrombospondin receptor alpha2delta-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. J Cell Biol. 2018 Oct 1;217(10):3747-3765
• All: 2 reference(s)