Nr0b2^em1Jskk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nr0b2^em1Jskk
• Name: nuclear receptor subfamily 0, group B, member 2; endonuclease-mediated mutation 1, Jongsook Kim Kemper
• MGI ID: MGI:7707359
• Synonyms: SHP-T58A
• Gene: Nr0b2 Location: Chr4:133280687-133283847 bp, + strand Genetic Position: Chr4, 66.25 cM
• Alliance: Nr0b2^em1Jskk page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced an ACC to GCA change resulting in a threonine to alanine substitution at amino acid 58 (p.T58A). Phosphorylation at Thr-58 is absent after treatment with FGF19. (J:352497)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr0b2 Mutation: 17 strains or lines available

References

• Original: J:352497 Kim YC, et al., Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease. J Biol Chem. 2023 Jun 20;299(8):104946
• All: 1 reference(s)