Tead2^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Tead2^{tm1c(EUCOMM)Wtsi}
• Name: TEA domain family member 2; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7705079
• Gene: Tead2 Location: Chr7:44865216-44882892 bp, + strand Genetic Position: Chr7, 29.19 cM, cytoband B5
• Alliance: Tead2^{tm1c(EUCOMM)Wtsi} page
• IMPC: Tead2 gene page

Mutation origin

• Mutant Cell Line: BEPD0211-F08
• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_Bact_P cassette was inserted into the loci The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site inserted upstream of exon 2. A third loxP site is inserted downstream of exon 2. The critical exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tead2 Mutation: 33 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)