Rr497^em1Zhhu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr497^em1Zhhu
• Name: regulatory region 497; endonuclease-mediated mutation 1, Zhengmao Hu
• MGI ID: MGI:7703159
• Synonyms: LOH-1-KO
• Gene: Rr497 Location: Chr3:128300731-128705731 bp Genetic Position: Chr3, Syntenic
• Alliance: Rr497^em1Zhhu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: A potential Pitx2 enhancer-containing region (GRCm39:chr3:128300731-128705731), equivalent to that deleted in Axenfeld-Rieger syndrome (ARS), was deleted using sgRNAs with CRISPR/Cas9 technology. (J:349012)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr497 Mutation: 0 strains or lines available

References

• Original: J:349012 Jiang Y, et al., Intergenic sequences harboring potential enhancer elements contribute to Axenfeld-Rieger syndrome by regulating PITX2. JCI Insight. 2024 Apr 9;9(9)
• All: 1 reference(s)