Rcor2^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Rcor2^{tm1b(EUCOMM)Wtsi}
• Name: REST corepressor 2; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:7665356
• Gene: Rcor2 Location: Chr19:7244759-7252590 bp, + strand Genetic Position: Chr19, 5.32 cM
• Alliance: Rcor2^{tm1b(EUCOMM)Wtsi} page
• IMPC: Rcor2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:350990
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 7246693 of Chromosome 19 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 7249164. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:350990)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rcor2 Mutation: 37 strains or lines available

References

• Original: J:350990 Rummukainen P, et al., The complex role of Rcor2: Regulates mesenchymal stromal cell differentiation in vitro but is dispensable in vivo. Bone. 2024 Jun 27;187:117180
• All: 1 reference(s)