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Rr483em1Mam
Endonuclease-mediated Allele Detail
Summary
Symbol: Rr483em1Mam
Name: regulatory region 483; endonuclease-mediated mutation 1, Lothar Hennighausen
MGI ID: MGI:7664592
Synonyms: Csn3-deltaE1
Gene: Rr483  Location: Chr5:88064501-88066580 bp  Genetic Position: Chr5, Syntenic
Alliance: Rr483em1Mam page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Modified regulatory region)
Mutation:    Intergenic deletion
 
Mutation detailsThe distal Csn3 enhancer was deleted using sgRNAs (equivalent to GGCTATCCATTTTCTGCTGTAGG, TTGTCCAACAGAGATTTTGTTGG and AAGTGAAGGTCAGCGTAATGAGG) with CRISPR/Cas9 technology, resulting in a 2080 bp deletion. (J:341588)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr483 Mutation:  0 strains or lines available
References
Original:  J:341588 Lee HK, et al., Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands. Nat Commun. 2023 Aug 17;14(1):4992
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory