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Del(5Rr482-Rr490)2Mam
Endonuclease-mediated Allele Detail
Summary
Symbol: Del(5Rr482-Rr490)2Mam
Name: deletion, chr 5, Lothar Hennighausen 2; deletion, Chr 5, Lothar Hennighausen 2
MGI ID: MGI:7664575
Synonyms: Csn2-deltaE2/3
Gene: Del(5Rr482-Rr490)2Mam  Location: unknown  Genetic Position: Chr5, Syntenic
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Modified regulatory region)
Mutation:    Intergenic deletion
 
Mutation detailsTwo Csn2 enhancers, Rr482 and Rr490, were deleted using sgRNAs (equivalent to GCTGTTCTTAATTCAGGCCCAGG and GAACTGGCCCTTATCATTACTGG) with CRISPR/Cas9 technology, resulting in a 9271 bp deletion. (J:341588)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(5Rr482-Rr490)2Mam Mutation:  0 strains or lines available
References
Original:  J:341588 Lee HK, et al., Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands. Nat Commun. 2023 Aug 17;14(1):4992
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory