Mir7b^tm1.2Stf
Targeted Allele Detail

Summary

• Symbol: Mir7b^tm1.2Stf
• Name: microRNA 7b; targeted mutation 1.2, Markus Stoffel
• MGI ID: MGI:7664489
• Synonyms: Mir7b KO
• Gene: Mir7b Location: Chr17:56549988-56550098 bp, + strand Genetic Position: Chr17, 29.23 cM
• Alliance: Mir7b^tm1.2Stf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242921
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted 97 bp upstream of the miRNA precursor sequence and a Frt-flanked neo cassette and second loxP site was inserted 498 bp downstream of the gene. The neo cassette was removed via FLP-mediated recombination and the loxP-flanked sequences were removed via Cre-mediated recombination in the germline. (J:242921)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir7b Mutation: 4 strains or lines available

References

• Original: J:242921 Ahmed K, et al., Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility. J Clin Invest. 2017 Mar 01;127(3):1061-1074
• All: 1 reference(s)