Cngb1^tm1Glf
Targeted Allele Detail

Summary

• Symbol: Cngb1^tm1Glf
• Name: cyclic nucleotide gated channel beta 1; targeted mutation 1, Gordon L Fain
• MGI ID: MGI:7664485
• Synonyms: Cngb1^neo
• Gene: Cngb1 Location: Chr8:95965673-96033213 bp, - strand Genetic Position: Chr8, 47.12 cM
• Alliance: Cngb1^tm1Glf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166744
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: The nucleotides within exon 20 encoding for 14 amino acids in the calmodulin binding domain were removed and a floxed neo cassette was inserted into intron 19 via homologous recombination. The inserted neo cassette sequence prevents expression of the gene until the cassette is removed via Cre-mediated recombination. (J:166744)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cngb1 Mutation: 59 strains or lines available

References

• Original: J:166744 Chen J, et al., Channel modulation and the mechanism of light adaptation in mouse rods. J Neurosci. 2010 Dec 1;30(48):16232-40
• All: 5 reference(s)