Gt(ROSA)26Sor^{tm1(CAG-SOX4)Vlf}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-SOX4)Vlf}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Veronique Lefevbre
• MGI ID: MGI:7664112
• Synonyms: R26^SOX4
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-SOX4)Vlf} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:350593
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-SOX4)Vlf} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOX4 (6659)

  Sox4	(MGI:98366)

• Mutation details: A CAG promoter, a loxP-flanked stop cassette containing a neomycin resistance (neo) cassette and three polyadenylation signals, and 3xFLAG tagged human SRY (sex determining region Y)-box 4 (SOX4) cDNA sequence followed by a polyadenylation signal was inserted into the Gt(ROSA)26Sor locus. (J:350593)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:350593 Angelozzi M, et al., SOXC are critical regulators of adult bone mass. Nat Commun. 2024 Apr 5;15(1):2956
• All: 1 reference(s)