Tbk1^em1Plxu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tbk1^em1Plxu
• Name: TANK-binding kinase 1; endonuclease-mediated mutation 1, Pinglong Xu
• MGI ID: MGI:7663909
• Synonyms: TBK1 S511E
• Gene: Tbk1 Location: Chr10:121382360-121422692 bp, - strand Genetic Position: Chr10, 69.84 cM
• Alliance: Tbk1^em1Plxu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9-mediated recombination inserted a TCT to GAA mutation resulting in an S511E substitution. (J:350509)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbk1 Mutation: 57 strains or lines available

References

• Original: J:350509 Zhang Q, et al., AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity. Mol Cell. 2022 Dec 1;82(23):4519-4536.e7
• All: 1 reference(s)