Shq1^tm1.1Key
Targeted Allele Detail

Summary

• Symbol: Shq1^tm1.1Key
• Name: SHQ1 homolog (S. cerevisiae); targeted mutation 1.1, Charles L Swayers
• MGI ID: MGI:7661068
• Synonyms: SHQ1^flox
• Gene: Shq1 Location: Chr6:100548772-100648135 bp, - strand Genetic Position: Chr6, 46.82 cM
• Alliance: Shq1^tm1.1Key page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250117
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Targeting vector HTGRS01000_A_A12 from IKMC Project 38364 consisting of the L1L2_Bact_P cassette composed of an FRT site followed by lacZ sequence and a loxP site, a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site, a second loxP site, and a third loxP site that is inserted downstream of the targeted exon 2 at position 100647145 was injected into 129 ES cells. The critical exon 2 is thus flanked by loxP sites. The lacZ and neomycin resistance gene were removed via flp-mediated recombination generating a conditional ready exon 2 floxed allele. (J:250117)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shq1 Mutation: 26 strains or lines available

References

• Original: J:250117 Hieronymus H, et al., Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis. Nat Commun. 2017 Oct 20;8(1):1081
• All: 1 reference(s)