Gata2^{em1(Ccnb1)Cfplu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gata2^{em1(Ccnb1)Cfplu}
• Name: GATA binding protein 2; endonuclease-mediated mutation 1, Carlos-Filipe Pereira
• MGI ID: MGI:7661030
• Synonyms: MD-Gata2
• Gene: Gata2 Location: Chr6:88170873-88184014 bp, + strand Genetic Position: Chr6, 39.2 cM
• Alliance: Gata2^{em1(Ccnb1)Cfplu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339095
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6N x 129/Sv)F1

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Gata2^{em1(Ccnb1)Cfplu} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ccnb1 (MGI:88302)	the mitotic degradation (MD) domain sequence

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gata2 Mutation: 29 strains or lines available

References

• Original: J:339095 Silverio-Alves R, et al., GATA2 mitotic bookmarking is required for definitive haematopoiesis. Nat Commun. 2023 Aug 14;14(1):4645
• All: 1 reference(s)