Ehf^tm1.2Joma
Targeted Allele Detail

Summary

• Symbol: Ehf^tm1.2Joma
• Name: ets homologous factor; targeted mutation 1.2, John M Mariadason
• MGI ID: MGI:7660974
• Synonyms: Ehf^KO
• Gene: Ehf Location: Chr2:103093776-103133620 bp, - strand Genetic Position: Chr2, 54.43 cM
• Alliance: Ehf^tm1.2Joma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 8 and the coding region of exon 9 were flanked by loxP sites. An inserted FRT-flanked neomycin cassette was removed via flp-mediated recombination. Exons 8 and the coding region of exon 9 were removed via cre-mediated recombination. (J:308742)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ehf Mutation: 26 strains or lines available

References

• Original: J:308742 Reehorst CM, et al., EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis. Development. 2021 Jun 15;148(12):dev199542
• All: 3 reference(s)