Dyrk1a^tm1.1Jdc
Targeted Allele Detail

Summary

• Symbol: Dyrk1a^tm1.1Jdc
• Name: dual-specificity tyrosine phosphorylation regulated kinase 1a; targeted mutation 1.1, John D Crispino
• MGI ID: MGI:7657948
• Gene: Dyrk1a Location: Chr16:94370869-94496376 bp, + strand Genetic Position: Chr16, 55.3 cM
• Alliance: Dyrk1a^tm1.1Jdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:349700
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5 and an FRT-flanked neomycin cassette and a loxP site was inserted downstream of exon 6. Cre-mediated recombination in the germline resulted in a deletion of the loxP flanked exon 5 and 6 sequences. (J:349700)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dyrk1a Mutation: 113 strains or lines available

References

• Original: J:349700 Cortes DE, et al., An in vitro neurogenetics platform for precision disease modeling in the mouse. Sci Adv. 2024 Apr 5;10(14):eadj9305
• All: 1 reference(s)