Kit^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kit^em1Cya
• Name: Kit proto-oncogene receptor tyrosine kinase; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7657288
• Synonyms: Kit^{em2(V831M)Cya}
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^em1Cya page

Mutation origin

• Strain of Origin: NOD.Cg-Prkdc^scid/Cya

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: The NKG-Kit*V831M mice was generated by introducing the KIT gene W41 mutation (V831M) into the background of NKG mice. Compared to NKG mice, NKG-Kit*V831M mice can undergo hematopoietic stem cell (HSC) reconstruction without irradiation, avoiding radiation-related side effects on mouse hematopoiesis, gastrointestinal tract, and nervous system. (J:326541)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 177 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)