H2-Ab1^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: H2-Ab1^em1Cya
• Name: histocompatibility 2, class II antigen A, beta 1; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7657258
• Synonyms: H2-Ab1^em1cya
• Gene: H2-Ab1 Location: Chr17:34482201-34488392 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Ab1^em1Cya page

Mutation origin

• Strain of Origin: NOD.Cg-Prkdc^scid/Cya

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: NKG-H2-Ab1 KO mice are generated by knocking out the H2-Ab1 gene on the background of NKG mice. Compared to NKG mice, NKG-H2-Ab1 KO mice can effectively reconstitute CD8+ T cells and exhibit improved survival after PBMC transplantation. They can be used for long-term studies on PBMC immune system reconstitution. (J:326541)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-Ab1 Mutation: 81 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)