Senp2^em1Jiabe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Senp2^em1Jiabe
• Name: SUMO/sentrin specific peptidase 2; endonuclease-mediated mutation 1, Jun-ichi Abe
• MGI ID: MGI:7645651
• Synonyms: SENP2 S344A KI
• Gene: Senp2 Location: Chr16:21828234-21868019 bp, + strand Genetic Position: Chr16, 12.98 cM, cytoband B1
• Alliance: Senp2^em1Jiabe page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Serine codon 343 (TCA) in exon 11 was changed to alanine (GCA) (p.S343A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation renders the affected residue unphosphorylatable in the encoded peptide. (J:347832)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Senp2 Mutation: 53 strains or lines available

References

• Original: J:347832 Nguyen MTH, et al., Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition. Front Cardiovasc Med. 2023;10:1187490
• All: 1 reference(s)