Trpv1^em1Yeyu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trpv1^em1Yeyu
• Name: transient receptor potential cation channel, subfamily V, member 1; endonuclease-mediated mutation 1, Ye Yu
• MGI ID: MGI:7645436
• Synonyms: Trpv1^T634A
• Gene: Trpv1 Location: Chr11:73125118-73152068 bp, + strand Genetic Position: Chr11, 45.25 cM, cytoband B3
• Alliance: Trpv1^em1Yeyu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Threonine codon 634 (ACA) in exon 13 was changed to alanine (GCA) (p.T634A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation blocks the proton-evoked (low pH) activation of the encoded peptide. (J:348664)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv1 Mutation: 65 strains or lines available

References

• Original: J:348664 Huang YZ, et al., TRPV1 analgesics disturb core body temperature via a biased allosteric mechanism involving conformations distinct from that for nociception. Neuron. 2024 Mar 11
• All: 1 reference(s)