Ifih1^tm1Hkato
Targeted Allele Detail

Summary

• Symbol: Ifih1^tm1Hkato
• Name: interferon induced with helicase C domain 1; targeted mutation 1, Hiroki Kato
• MGI ID: MGI:7643806
• Synonyms: MDA5 G821S
• Gene: Ifih1 Location: Chr2:62426142-62476599 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C3
• Alliance: Ifih1^tm1Hkato page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:347912
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Single point mutation
• Mutation details: Glycine codon 821 (GGT) in exon 13 was changed to serine (AGT) (p.G821S) and a loxP site, a copy of the 5' end of exon 13, a stop codon, poly(A) signal sequence, a neomycin resistance gene cassette and a second loxP site were inserted into intron 12. This is a null allele owing to the premature stop codon. Only after Cre-mediated removal of the duplicate exon 13 sequence and STOP cassette will it express the mutated transcript and peptide. (J:347912)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifih1 Mutation: 50 strains or lines available

References

• Original: J:347912 Luca D, et al., Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity. Sci Adv. 2024 Mar;10(9):eadk0820
• All: 1 reference(s)