Ing5^tm1.2Avo
Targeted Allele Detail

Summary

• Symbol: Ing5^tm1.2Avo
• Name: inhibitor of growth family, member 5; targeted mutation 1.2, Anne K Voss
• MGI ID: MGI:7643725
• Synonyms: Ing5^fl
• Gene: Ing5 Location: Chr1:93731687-93749823 bp, + strand Genetic Position: Chr1, 47.34 cM, cytoband D
• Alliance: Ing5^tm1.2Avo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345308
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert loxP sites flanking exons 3-5, encoding part of the N-terminal ING domain and the nuclear localization signal, of the inhibitor of growth family, member 5 (Ing5) gene, and a frt-flanked neomycin resistance (neo) cassette was also inserted downstream of the 5' loxP site. FLPe-mediated recombination removed the neo cassette. (J:345308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ing5 Mutation: 24 strains or lines available

References

• Original: J:345308 Mah SYY, et al., The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver. Front Immunol. 2023;14:1119750
• All: 2 reference(s)