Slc8a1^em1Motto
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc8a1^em1Motto
• Name: solute carrier family 8 (sodium/calcium exchanger), member 1; endonuclease-mediated mutation 1, Michela Ottolia
• MGI ID: MGI:7643600
• Synonyms: NCX1 K229Q
• Gene: Slc8a1 Location: Chr17:81680534-82045806 bp, - strand Genetic Position: Chr17, 51.29 cM
• Alliance: Slc8a1^em1Motto page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Lysine codon 261 (AAG) in exon 1 was changed to glutamine (CAG) (p.K261Q) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation blocks the Na⁺-dependent inactivation of the encoded peptide. (J:348093)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc8a1 Mutation: 57 strains or lines available

References

• Original: J:348093 Scranton K, et al., Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1. Nat Commun. 2024 May 7;15(1):3831
• All: 2 reference(s)