Rr477^em1Mtor
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr477^em1Mtor
• Name: regulatory region 477; endonuclease-mediated mutation 1, Miguel Torres
• MGI ID: MGI:7642209
• Synonyms: Myc^GFPdelta2
• Gene: Rr477 Location: Chr15:61880296-61886183 bp Genetic Position: Chr15, Syntenic
• Alliance: Rr477^em1Mtor page

Mutation origin

• Strain of Origin: 129

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: ES cells containing the Myc^tm1Slek allele were targeted with crRNAs to delete Myc early embryonic enhancer 2 (NPE (naive pluripotency enhancer)). (J:348281)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr477 Mutation: 0 strains or lines available

References

• Original: J:348281 Li-Bao L, et al., Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression. Nat Commun. 2024 May 10;15(1):3931
• All: 1 reference(s)