Tg(Myc/TFP)#Mtor
Transgene Detail

Summary

• Symbol: Tg(Myc/TFP)#Mtor
• Name: transgene insertion, Miguel Torres
• MGI ID: MGI:7642199
• Synonyms: Myc^2TFP
• Transgene: Tg(Myc/TFP)#Mtor Location: unknown Genetic Position: Chr15, Syntenic
• Alliance: Tg(Myc/TFP)#Mtor page

Transgene origin

• Strain of Origin: C57BL/6JCrl

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Myc/TFP)#Mtor expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myc (MGI:97250)

• Mutation details: Mouse chr15 BAC RP24-78D24, which contains the Myc gene (as well as the 5' end of the Pvt1 gene), was modified through the insertion of the TFP (turquoise fluorescent protein) gene in-frame with the start of the Myc gene coding region in exon 2. Copy number analysis and whole genome sequencing revealed that two copies of the transgene inserted into chr15, downstream of the endogenous Myc gene: the first copy has a 35 kb deletion in the 3' end of the BAC (containing putative regulatory regions), the second copy is complete. The two copies are separated by 306 kb of chr19 sequence, duplicated from a location around GRCm39:chr19:42,000,000. (J:348281)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:348281 Li-Bao L, et al., Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression. Nat Commun. 2024 May 10;15(1):3931
• All: 1 reference(s)