Pkd2^tm1.1Witz
Targeted Allele Detail

Summary

• Symbol: Pkd2^tm1.1Witz
• Name: polycystin 2, transient receptor potential cation channel; targeted mutation 1.1, Ralph Witzgall
• MGI ID: MGI:7642134
• Synonyms: Pkd2^poreL1
• Gene: Pkd2 Location: Chr5:104607316-104653685 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Pkd2^tm1.1Witz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327006
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A mutated exon 8, floxed neomycin resistance cassette, mutated exon 9, wild-type exon 10, replaced exons 8-10. The neomycin resistance cassette was removed via cre-mediated recombination. Exons 8 and 9 encode the pore region and the mutations exchange the pore loop with that of the closely related cation channel polycystin-2L1. (J:327006)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd2 Mutation: 85 strains or lines available

References

• Original: J:327006 Grosch M, et al., A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts. J Cell Sci. 2021 Aug 15;134(16):jcs259013
• All: 1 reference(s)