Pinlyp^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Pinlyp^tm1.1Bcgen
• Name: phospholipase A2 inhibitor and LY6/PLAUR domain containing; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:7639783
• Synonyms: PINLYP^fl
• Gene: Pinlyp Location: Chr7:24241083-24245543 bp, - strand Genetic Position: Chr7, 11.38 cM
• Alliance: Pinlyp^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322222
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exons 2-5 and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. (J:322222)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pinlyp Mutation: 15 strains or lines available

References

• Original: J:322222 Liu Z, et al., Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2111115119
• All: 1 reference(s)