Avpr1a^tm1.2Hokh
Targeted Allele Detail

Summary

• Symbol: Avpr1a^tm1.2Hokh
• Name: arginine vasopressin receptor 1A; targeted mutation 1.2, Hitoshi Okamura
• MGI ID: MGI:7639762
• Synonyms: V1a^-
• Gene: Avpr1a Location: Chr10:122284404-122289357 bp, + strand Genetic Position: Chr10, 70.36 cM, cytoband D3
• Alliance: Avpr1a^tm1.2Hokh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:347259
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region in exon 2 was flanked by loxP sites. The inserted FRT-flanked neomycin selection cassette was removed via flp-mediated recombination. The coding region of exon 2 was deleted via cre-mediated recombination. (J:347259)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Avpr1a Mutation: 40 strains or lines available

References

• Original: J:347259 Yamaguchi Y, et al., An intact pituitary vasopressin system is critical for building a robust circadian clock in the suprachiasmatic nucleus. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2308489120
• All: 1 reference(s)