Zp2^em1Sgao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zp2^em1Sgao
• Name: zona pellucida glycoprotein 2; endonuclease-mediated mutation 1, Shaorong Gao
• MGI ID: MGI:7639700
• Synonyms: Zp2^mut
• Gene: Zp2 Location: Chr7:119725995-119744514 bp, - strand Genetic Position: Chr7, 64.38 cM
• Alliance: Zp2^em1Sgao page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Serine codon 667 (AGC) was changed to a stop codon (TAA) (p.S667*) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of a similar human mutation (NM_003460.2:c.2092C>T:p.R698*) associated with female infertility. (J:302592)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zp2 Mutation: 48 strains or lines available

References

• Original: J:302592 Liu W, et al., Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility. Hum Genet. 2017 Aug;136(8):975-985
• All: 1 reference(s)