Itgam^tm1.1Rivp
Targeted Allele Detail

Summary

• Symbol: Itgam^tm1.1Rivp
• Name: integrin alpha M; targeted mutation 1.1, Roberto I Vazquez-Padron
• MGI ID: MGI:7638771
• Synonyms: CD11b^I332G
• Gene: Itgam Location: Chr7:127661812-127717663 bp, + strand Genetic Position: Chr7, 69.93 cM, cytoband F4
• Alliance: Itgam^tm1.1Rivp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301826
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Isoleucine codon 332 (ATC) in exon 9 was changed to glycine (GGC) (p.I332G) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 8. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation renders the encoded peptide constitutively active. (J:301826)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgam Mutation: 49 strains or lines available

References

• Original: J:301826 Martinez L, et al., A Genetic Model of Constitutively Active Integrin CD11b/CD18. J Immunol. 2020 Nov 1;205(9):2545-2553
• All: 1 reference(s)