Notch3^tm1.1Jkit
Targeted Allele Detail

Summary

• Symbol: Notch3^tm1.1Jkit
• Name: notch 3; targeted mutation 1.1, Jan K Kitajewski
• MGI ID: MGI:7628738
• Synonyms: Notch3^flox
• Gene: Notch3 Location: Chr17:32339794-32385826 bp, - strand Genetic Position: Chr17, 17.37 cM
• Alliance: Notch3^tm1.1Jkit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301745
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the promoter region, and a Frt-Neo-Frt-LoxP (FNFL) cassette was inserted in the intron downstream of exon1. The frt-flanked neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:301745)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch3 Mutation: 96 strains or lines available

References

• Original: J:301745 Nadeem T, et al., Deficiency of Notch signaling in pericytes results in arteriovenous malformations. JCI Insight. 2020 Nov 5;5(21)
• All: 2 reference(s)