Gramd1b
Targeted Allele Detail

Summary

• Symbol: Gramd1b
• Name: GRAM domain containing 1B; targeted mutation 1.2, Peter Tontonoz
• MGI ID: MGI:7626306
• Gene: Gramd1b Location: Chr9:40204529-40442679 bp, - strand Genetic Position: Chr9, 21.42 cM, cytoband B
• Alliance: Gramd1b page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342939
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-6 of the macrophage specific variant (exons 6-9 of the intestine specific variant) were flanked with loxP sites and a self-excising neo cassette inserted via homologous recombination. After insertion the neo cassette was excised. Cre mediated recombination removed the floxed region. (J:342939)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gramd1b Mutation: 120 strains or lines available

References

• Original: J:342939 Ferrari A, et al., Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake. Science. 2023 Nov 10;382(6671):eadf0966
• All: 1 reference(s)