Thpo^em1.1Suda
Endonuclease-mediated Allele Detail

Summary

• Symbol: Thpo^em1.1Suda
• Name: thrombopoietin; endonuclease-mediated mutation 1.1, Toshio Suda
• MGI ID: MGI:7625655
• Gene: Thpo Location: Chr16:20543204-20553261 bp, - strand Genetic Position: Chr16, 12.51 cM
• Alliance: Thpo^em1.1Suda page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology was used to flank exons 2 and 3 with loxP sites. Cre-mediated recombination in the germline resulted in the deletion of exons 2 and 3. (J:270782)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thpo Mutation: 20 strains or lines available

References

• Original: J:270782 Nakamura-Ishizu A, et al., Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation. Cell Rep. 2018 Nov 13;25(7):1772-1785.e6
• All: 1 reference(s)