Gla^tm1Rjde
Targeted Allele Detail

Summary

• Symbol: Gla^tm1Rjde
• Name: galactosidase, alpha; targeted mutation 1, Robert Desnick
• MGI ID: MGI:7624486
• Gene: Gla Location: ChrX:133488912-133501707 bp, - strand Genetic Position: ChrX, 56.2 cM, cytoband E-F1
• Alliance: Gla^tm1Rjde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66863
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Molecular details are not reported. Affected mice were reported to be totally deficient in Gla activity. (J:66863)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gla Mutation: 20 strains or lines available

References

• Original: J:66863 Ioannou YA, et al., Fabry disease: preclinical studies demonstrate the effectiveness of alpha-galactosidase A replacement in enzyme-deficient mice. Am J Hum Genet. 2001 Jan;68(1):14-25
• All: 5 reference(s)