Clec10a^em1Shib
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clec10a^em1Shib
• Name: C-type lectin domain family 10, member A; endonuclease-mediated mutation 1, Akira Shibuya
• MGI ID: MGI:7624329
• Synonyms: Clec10a^c.706C
• Gene: Clec10a Location: Chr11:70057449-70061662 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Clec10a^em1Shib page

Mutation origin

• Strain of Origin: NC/Nga

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: The spontaneous NM_010796:c.706C>T:p.Q236* mutation in exon 9 that occurs in the NC/Nga strain was reverted to the major C variant (found in C57BL/6 and most other strains) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. (J:283174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec10a Mutation: 27 strains or lines available

References

• Original: J:283174 Kanemaru K, et al., Clec10a regulates mite-induced dermatitis. Sci Immunol. 2019 Dec 6;4(42)
• All: 1 reference(s)