Pabpn1l^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pabpn1l^em1Osb
• Name: poly(A)binding protein nuclear 1-like; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7621900
• Gene: Pabpn1l Location: Chr8:123346210-123349474 bp, - strand Genetic Position: Chr8, 71.93 cM
• Alliance: Pabpn1l^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 13-bp deletion in the first exon, which results in a predicted premature stop codon at amino acid 79 of the encoded protein. (J:345444)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Pabpn1l Mutation: 11 strains or lines available

References

• Original: J:345444 Emori C, et al., PABPN1L is required for maternal mRNA degradation after meiosis resumption. J Reprod Dev. 2023 Dec 7
• All: 1 reference(s)