Tg(Chrna6*L280S)2Lst
Transgene Detail

Summary

• Symbol: Tg(Chrna6*L280S)2Lst
• Name: transgene insertion 2, Henry A Lester
• MGI ID: MGI:7621679
• Synonyms: alpha6^L9'S
• Transgene: Tg(Chrna6*L280S)2Lst Location: unknown
• Alliance: Tg(Chrna6*L280S)2Lst page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene consists of mouse BAC RP24-149I12 where leucine codon 280 (CTT) in exon 5 was changed to serine (TCA) (p.L280S). The mutation is located at L9' in the second transmembrane region of the encoded peptide and affects its acetylcholine and nicotine affinities. The BAC also contains the Chrnb3 gene, which was disabled through the insertion of an ampicillin cassette at the start codon. (J:149871)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:149871 Drenan RM, et al., In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors. Neuron. 2008 Oct 9;60(1):123-36
• All: 1 reference(s)