Noxa1^tm1.1Mrng
Targeted Allele Detail

Summary

• Symbol: Noxa1^tm1.1Mrng
• Name: NADPH oxidase activator 1; targeted mutation 1, Marschall S Runge
• MGI ID: MGI:7621673
• Synonyms: Noxa1^-
• Gene: Noxa1 Location: Chr2:24975679-24985161 bp, - strand Genetic Position: Chr2, 16.97 cM
• Alliance: Noxa1^tm1.1Mrng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279190
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The entire coding region spaning 12 exaons of the NADPH oxidase activator 1 (Noxa1) gene was replaced with a neomycin resistance (neo) cassette flanked by loxP and frt sites by targeted homologous recombination in ES cells. The neo cassette was removed by crossing with FLPe expressing mice. (J:279190)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Noxa1 Mutation: 19 strains or lines available

References

• Original: J:279190 Vendrov AE, et al., NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis. Redox Biol. 2019 Feb;21:101063
• All: 1 reference(s)