Ola1^tm1.1Chin
Targeted Allele Detail

Summary

• Symbol: Ola1^tm1.1Chin
• Name: Obg-like ATPase 1; targeted mutation 1.1, Natsuko Chiba
• MGI ID: MGI:7621386
• Gene: Ola1 Location: Chr2:72923145-73044791 bp, - strand Genetic Position: Chr2, 43.35 cM, cytoband C3
• Alliance: Ola1^tm1.1Chin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:347096
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed exon 3 and the neo cassette. (J:347096)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ola1 Mutation: 31 strains or lines available

References

• Original: J:347096 Yoshino Y, et al., Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification. Biochim Biophys Acta Mol Basis Dis. 2024 Mar 26;1870(5):167138
• All: 1 reference(s)