Ecsit^tm2.1Gho
Targeted Allele Detail

Summary

• Symbol: Ecsit^tm2.1Gho
• Name: ECSIT signalling integrator; targeted mutation 2.1, Sankar Ghosh
• MGI ID: MGI:7620369
• Synonyms: Ecsit^f
• Gene: Ecsit Location: Chr9:21983542-21996734 bp, - strand Genetic Position: Chr9, 8.23 cM, cytoband A4
• Alliance: Ecsit^tm2.1Gho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271638
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 3 floxed. (J:271638)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ecsit Mutation: 13 strains or lines available

References

• Original: J:271638 Carneiro FRG, et al., An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages. Cell Rep. 2018 Mar 6;22(10):2654-2666
• All: 2 reference(s)