Traf6^tm1.1Pcoh
Targeted Allele Detail

Summary

• Symbol: Traf6^tm1.1Pcoh
• Name: TNF receptor-associated factor 6; targeted mutation 1.1, Philip Cohen
• MGI ID: MGI:7620319
• Synonyms: TRAF6[L74H]
• Gene: Traf6 Location: Chr2:101508774-101532014 bp, + strand Genetic Position: Chr2, 53.9 cM
• Alliance: Traf6^tm1.1Pcoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242239
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Leucine codon 74 (TTG) in exon 3 was changed to histidine (p.L74H) and an FRT site flanked puromycin resistance gene cassette was inserted into intron 2. The puro cassette was removed through subsequent Flp-mediated recombination. The mutation renders the encoded peptide catalytically inactive. (J:242239)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf6 Mutation: 32 strains or lines available

References

• Original: J:242239 Strickson S, et al., Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3481-E3489
• All: 2 reference(s)